OBJECTIVES

  1. Optimization of isolation and culture procedures of solid tumor-derived TAFs in order to obtain highly homogenous cellular populations
  2. In vitro identification of TAF specific morphological and functional markers. Comparative analysis of TAFs and MSCs.

RESULTS


SCIENTIFIC REPORT


PUBLICATIONS

  1. Bojin F, Gruia A, Ordodi V, Mic F, Marusciac L, Gavriliuc O, Tatu CA, Paunescu V. Features of lipid metabolism along differentiation pathway of human mesenchymal stem cells towards mature adipocytes. PLOS One, 2012.
  2. Cean A, Istratoaie B, Cristea M, Ivan A, Anghel S, Bojin F, Tanasie G, Tatu C, Panaitescu C, Paunescu V. The morphology of colonies from breast cancer SK-BR-3 cells in semisolid media depends on the media composition. Fiziologia - Physiology, 2012; 22(75): 9-14.

NATIONAL SCIENTIFIC MEETINGS

  1. Bojin F, Ordodi V, Gavriliuc O, Cristea M, Anghel S, Gruia A, Mic FA, Cean A, Lazarovicz R, Toma M, Marusciac L, Tanasie G, Tatu C, Panaitescu C, Paunescu V. In vitro models of adipogenesis for understanding molecular mechanisms underlying occurrence of obesity. Conference and Advanced Translational Research Workshop: Chronic Diseases – From Pathogenesis to Therapy, 25-27 October 2012, Timisoara. Abstract book pg. 37, ISBN 978-606-8054-93-3.
  2. Cernescu L, Toma M, Bojin F, Gavriliuc O, Anghel S, Cristea M, Gruia A, Tatu C, Tanasie G, Panaitescu C, Paunescu V. Proliferative potential of double positive CD4+/CD8+ T cells in co-culture sytem with tumor cells. The 24nd Annual Immunology Conference, 27-29 September 2012, Bucharest. Abstract Book pg. 102, ISBN 978-606-8003-24-5.
  3. Bojin F, Ordodi V, Anghel S, Cristea M, Gavriliuc O, Marusciac L, Toma M, Lazarovicz R, Panaitescu C, Paunescu V. Na+/K+ - ATP-ase blockers inhibit functionality of bone marrow-derived mesenchymal stem cells. Conference and Advanced Research Workshop – Sudden Cardiac Death & Cardioprotection, 6-9 September 2012, Timisoara. Abstract Book pg. 97, ISBN 978-606-8054-80-3; 978-963-306-162-6.
  4. Bojin F, Ordodi V, Cristea M, Anghel S, Gruia A, Tanasie G, Tatu C, Panaitescu C, Paunescu V. Introspection in molecular expression pattern of human mesenchymal stem cells-differentiated adipocytes. Academician Nicolae Cajal Symposium, Bucharest, March 28-31 2012, Abstract book pg. 10
  5. Paunescu V, Bojin F, Ordodi V, Gavriliuc O, Cristea M, Anghel S, Gruia A, Mic FA, Tanasie G, Tatu C, Panaitescu C. Molecular expression pattern of human mesenchymal stem cells-differentiated adipocytes. Fiziologia-Physiology, 2012; supplement: 22 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.
  6. Anghel S, Bojin F, Tatu CA, Ordodi V, Gruia A, Rosca A, Tanasie G, Tatu C, Panaitescu C, Paunescu V. Differentiation mechanisms and pathways of dog periosteum-derived stem cells. Fiziologia-Physiology, 2012; supplement: 30 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.
  7. Bojin F, Ordodi V, Gavriliuc O, Cristea M, Anghel S, Gruia A, Nistor D, Crisnic D, Boleman A, Tanasie G, Tatu C, Panaitescu C, Paunescu V. Na/K pump inhibitors decrease proliferation of normal and tumor cells. Fiziologia-Physiology, 2012; supplement: 34 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.
  8. Cristea M, Bojin F, Gai E, Rosca A, Tatu C, Paunescu V. Anti-tumoral effects of Aristolochia clematitis aqueous extract on tumor cell lines. Fiziologia-Physiology, 2012; supplement: 39 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.
  9. Deica M, Sima R, Cernat L, Cristea M, Bojin F, Paunescu V. Effects of chemotherapeutic drugs and adjuvant therapy mixtures on normal and tumor cells – in vitro studies. Fiziologia-Physiology, 2012; supplement: 40 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.
  10. Gai E, Gruia A, Boldeanu F, Cristea M, Bojin F, Serban M, Arghirescu S, Jinca C, Balint Gib L, Ordodi V, Dumitrascu V, Tatu C, Lungeanu D, Paunescu V. Frequency of HLA-A allele correlated with high risk of hematological diseases. Fiziologia-Physiology, 2012; supplement: 43 - The 11th National Congress of the Romanian Society of Physiological Sciences, 10-12 May, Timisoara, Romania.

INTERNATIONAL SCIENTIFIC MEETINGS

  1. Bojin F, Gavriliuc OI, Cristea MI, Gruia AT, Anghel S, Tatu CS, Tanasie G, Panaitescu C, Tatu CA, Paunescu V. Ouabain inhibits in vitro proliferation of tumour-associated fibroblasts and cancer cell lines. European Journal of Cancer 48, Suppl. 5 (2012): S52; Proceedings Book, 22nd Biennial Congress of the European Association of Cancer Research – From basic research to personalized cancer treatment, 7-10 July 2012, Barcelona, Spain.